Gloria López‐Castejón

This study uses reporter mice to visualise NLRP3 inflammasomes in vivo, revealing their localisation, organisation, and cellular sources.

This study disrupts the nuclear localisation sequence of endogenous IL-1α in mice and examines its effects on inflammatory responses, finding no significant changes in LPS-induced transcriptional signatures or IL-1 release.

This study shows that deleting CH25H and LIPA genes in humans eliminates 25-hydroxycholesterol but not 7alpha,25-dihydroxysterols, and increases cholesterol oxidation, which is partially reversed by hematopoietic stem cell transplant.

This study investigates how lysosome positioning affects NLRP3 inflammasome activation in HeLa and macrophage cells, finding that peripheral lysosome positioning enhances inflammasome activation.

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.