This study identifies a novel S1PR1-Dll4-MPDZ-Notch1 signaling pathway that enhances endothelial barrier integrity through Notch activation and Rac1 activity.

bioRxiv · May 21, 2026 · PreprintCell Biology

Synthetic Control of Implanted Engineered Liver Tissue Growth

Amy E. Stoddard, Vardhman Kumar, Constantine N. Tzouanas, Veronica W. Hui, Jeffrey Ji-Peng Li, Anisha Jain, Alanna M. Farrell, Sangeeta N. Bhatia, Christopher S. Chen

This paper develops a method to grow engineered liver tissue in vivo by using synthetic biology to trigger on-demand expansion after implantation.

Science Advances · Apr 17, 2026Peer-reviewedBioengineering

Image-Guided Injectable Niche for Hepatocyte Transplantation

Vardhman Kumar, Joa Yun, Susanna K. Elledge, Nicole Henning, Katarzyna A. Grzelak, Ashley D. Westerfield, Amy E. Stoddard, Favour A. Oladimeji, Virginia Ch. Spanoudaki, Kasturi Chakraborty, Savan K. Patel, Heather E. Fleming, Christopher S. Chen, Sangeeta N. Bhatia

The paper develops INSITE, an injectable platform for hepatocyte transplantation that enables precise delivery and long-term function through image-guided assembly into vascularizable scaffolds.

Cell Biomaterials · Mar 3, 2026Peer-reviewedBioengineering

Differentiation of human intestinal organoids with endogenous vascular endothelial cells

Emily M. Holloway, Joshua H. Wu, Michael J. Czerwinski, Caden W. Sweet, Angeline Wu, Yu-Hwai Tsai, Sha Huang, Amy E. Stoddard, Meghan M. Capeling, Ian A. Glass, Jason R. Spence

This study enhances the co-differentiation of intestinal organoids with endothelial cells, showing they share an intestinal-specific transcriptional signature with native cells.

Developmental Cell · Aug 1, 2020Peer-reviewedDevelopmental Biology