Christopher S. Chen

This paper develops a biophysical platform to deliver electromechanical stimulation to engineered cardiac tissues and shows that synchronized stimulation increases contractile force.

PROPEL applies programmable shear stress to endothelial cells, revealing subtype-specific mechanoadaptation thresholds and transcriptional responses across vascular beds.

This study identifies a novel S1PR1-Dll4-MPDZ-Notch1 signaling pathway that enhances endothelial barrier integrity through Notch activation and Rac1 activity.

This study shows electrical stimulation promotes the formation of functional, perfusable vasculature in engineered tissues by inducing endothelial cell hyperpolarization via KV channels.

This paper develops a 3D in vitro model of the human hepatobiliary junction that recapitulates bile flow and dysfunction under hypoxia-reoxygenation, offering insights into biliary pathophysiology.

This paper develops a method to grow engineered liver tissue in vivo by using synthetic biology to trigger on-demand expansion after implantation.

The paper develops INSITE, an injectable platform for hepatocyte transplantation that enables precise delivery and long-term function through image-guided assembly into vascularizable scaffolds.

This study shows Bmp9 upregulates Lunatic Fringe in endothelial cells, enhancing Notch signaling and regulating angiogenesis dynamics.

This paper develops a 3D computational model of microvascular beds and interstitial spaces to better understand fluid flow dynamics and the effects of vascular permeability.

This paper introduces a fluorescein-based SynNotch system to regulate gene expression in response to extracellular cues, demonstrating its use in controlling myogenic conversion.

This study shows perivascular cells sense mechanical changes in collagen matrix, affecting vascular function and contributing to fibrotic conditions.

This study develops a scalable method to expand primary human hepatocytes while preserving their function, enabling improved liver cell therapy.

The paper maps EMT transitions through multi-omic profiling, identifies key regulatory factors, and reveals discordance between molecular layers in human mammary epithelial cells.