Alexander M. Marzilli

Engineered Allosteric RNA Editors Enable Compact, Stimulus-Responsive Post-Transcriptional Circuits

This paper introduces iDARs, inducible deaminases that enable stimulus-responsive RNA editing, allowing controlled protein translation or transcript degradation in response to various triggers.

RNA-Stabilized Coat Proteins for Sensitive and Simultaneous Imaging of Distinct Single mRNAs in Live Cells

This paper introduces RNA-stabilized coat proteins for low-background live-cell RNA imaging, enabling sensitive visualization of single mRNAs and dual-color imaging of distinct RNA species.

Fluorescein-Based SynNotch Adaptors for Regulating Gene Expression Responses to Diverse Extracellular Cues

This paper introduces a fluorescein-based SynNotch system to regulate gene expression in response to extracellular cues, demonstrating its use in controlling myogenic conversion.

Tension-Tuned SynNotch Receptors for Synthetic Mechanotranduction and Intercellular Force Detection

This paper introduces tension-tuned SynNotch receptors that convert mechanical forces into gene expression changes, enabling synthetic mechanosensing and intercellular force detection.