Jeremy C. Tran

ProNotch converts extracellular protease activity into programmable transcriptional outputs by using a modular receptor system that responds to protease cleavage.

This paper introduces a fluorescein-based SynNotch system to regulate gene expression in response to extracellular cues, demonstrating its use in controlling myogenic conversion.

This paper introduces tension-tuned SynNotch receptors that convert mechanical forces into gene expression changes, enabling synthetic mechanosensing and intercellular force detection.