Stina Syvänen

Brain-Penetrating Peptide and Antibody Radioligands for Proof-of-Concept PET Imaging of Fibrin in Alzheimer's Disease

This paper develops and evaluates PET radioligands targeting fibrin in Alzheimer's disease brains, showing that bispecific antibodies have better fibrin selectivity and brain penetration than peptide conjugates.

Radionuclide selection influences imaging outcomes in immunoPET with a brain-penetrant anti-Aβ antibody

This paper compares three radionuclides for immunoPET imaging of a bispecific anti-Aβ antibody in a mouse model, finding that 89Zr and 124I provide distinct advantages in brain uptake and contrast.

Cryo-EM Structures of Amyloid-β Fibrils from Alzheimer's Disease Mouse Models

The paper presents cryo-EM structures of Aβ fibrils from Alzheimer's disease mouse models and compares them to human fibrils.