Martin Ingelsson

This study links obesity and type 2 diabetes to Alzheimer's disease through genetic and transcriptomic analyses, identifying shared pathways and potential drug targets.

This study compares soluble α-synuclein species from MSA and LBD brains, finding differences in their seeding activity and size distribution.

This study investigates whether distinct α-synuclein strains contribute to clinical subtypes of multiple system atrophy (MSA) and finds no differences in strain properties between MSA-C and MSA-P.

This study compares four methods of purifying α-synuclein for seed amplification assays, finding that osmotic shock-purified monomer has the lowest aggregation propensity and best inter-batch reproducibility.

The paper investigates the relationship between loss of Y chromosome (LOY) and clonal hematopoiesis in Alzheimer's disease patients, finding that LOY drives myeloid clones which may accumulate additional mutations.

The paper identifies Rps24c/S24-PKE as a novel marker for neuroinflammation and neurodegeneration through cell type-specific alternative splicing in mouse brains.

The paper analyzes exome data from 22,319 individuals to identify rare CNVs and 22q11.21 dosage as risk factors for Alzheimer's disease.

The paper presents cryo-EM structures of Aβ fibrils from Alzheimer's disease mouse models and compares them to human fibrils.

The paper identifies multi-omic changes in immune cells from Alzheimer's disease patients with loss of Y, linking LOY to epigenetic and gene expression alterations.

The paper uses snRNA-seq to analyze TBI brain tissue, finding oligodendroglia activate endogenous retroviruses, linking them to neuroinflammation.

This study investigates how nucleus size affects spatial transcriptomics results and introduces CSDI to improve accuracy in analyzing consecutive tissue slices.

The paper introduces a method to estimate intra-individual changes in mosaic loss of chromosome Y (LOY) over time using standardized SNP-array data, showing higher correlation with other methods and significant individual variation.

The paper identifies genetic determinants of mosaic Y chromosome loss in blood and links it to genomic instability and non-haematological cancer risk.

This study fine-maps type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps, identifying 73 variants with >80% posterior probability of association.