Fernanda S. Peralta Reyes

This paper shows lecanemab binds to amyloid-β fibrils from Alzheimer's disease mouse models with flexible N-termini, including type-I, type-II, and Arctic folds, but not those with fixed N-termini like in tg-SwDI mice.

The paper presents cryo-EM structures of Aβ fibrils from Alzheimer's disease mouse models and compares them to human fibrils.

The paper identifies that excitatory and inhibitory parvalbumin interneurons in the spinal dorsal horn form distinct circuits and that excitatory interneurons contribute to mechanical hypersensitivity under pathological conditions.