George B. Ploubidis

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

The paper identifies genetic impacts on DNA methylation across 724,499 CpGs in blood samples, revealing co-localisations with disease traits and regulatory mechanisms.

This study maps DNA methylation changes across the human life course using data from 7,037 individuals, showing increased variability and age-related mean changes at specific CpG sites.