Juan Castillo Fernandez

Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects

The paper identifies vmeQTLs for blood DNA methylation variance in MZ twins, showing gene-environment interactions and cell-type effects relevant to immune disease.

Genetic impacts on DNA methylation help elucidate regulatory genomic processes

The paper identifies genetic impacts on DNA methylation across 724,499 CpGs in blood samples, revealing co-localisations with disease traits and regulatory mechanisms.

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

This study identifies DNA methylation changes associated with extreme obesity and finds causal effects on obesity and metabolic disturbances using Mendelian Randomisation.

Multi-omics analysis demonstrates a critical role for GLP methyltransferase in transcriptional repression during oogenesis

The paper investigates the role of GLP methyltransferase in oocyte development using multi-omics analysis and mouse models, finding that GLP contributes to transcriptional repression and is critical for oogenesis.

Characterizing the human methylome across the life course: findings from eight UK-based studies

This study maps DNA methylation changes across the human life course using data from 7,037 individuals, showing increased variability and age-related mean changes at specific CpG sites.

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

Differentially methylated regions and methylation QTLs for teen depression and early puberty in the Fragile Families Child Wellbeing Study

The paper identifies differentially methylated regions and methylation QTLs associated with teen depression and early puberty using longitudinal DNA methylation data from the Fragile Families Child Wellbeing Study.

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

This study identifies DNA methylation sites associated with coffee and tea consumption using EWAS, finding potential links to fatty liver disease through PHGDH expression.

Epigenetic change induced by in utero dietary challenge provokes phenotypic variability across multiple generations of mice

The paper shows that maternal high-fat diet induces epigenetic changes in mice that affect two generations, with altered Dlk1 expression and DNA methylation.

Epigenetic findings in periodontitis in UK twins: a cross sectional study

This study identifies DNA methylation changes in blood and tissue samples associated with periodontal disease in older female twins.

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

This study identifies smoking-associated DNA methylation and gene expression changes in adipose tissue and links some to cardio-metabolic health outcomes.