Stephen D. R. Harridge

CD55-CD319-CX3CR1 flow cytometry gating strategy recapitulates scRNA-seq-defined memory CD8 T cell subpopulations

This paper develops a flow cytometry gating strategy using CD55, CD319, and CX3CR1 to identify transcriptionally defined CD8 T cell subpopulations, improving resolution over conventional methods.

Increased utrophin expression in healthy and DMD patient derived myoblasts in response to ERK1/2 and EZH2 inhibitor treatment

The paper shows that ERK1/2 and EZH2 inhibitors increase utrophin expression in myoblasts from healthy and DMD patients, with sustained effects in patient-derived cells.

SIMON: open-source knowledge discovery platform

SIMON is an open-source platform that enables biomedical researchers to apply machine learning algorithms to high-dimensional data without requiring advanced programming skills.