Janet M. Lord

This study identifies aetiology-specific molecular mechanisms of sarcopenia in end-stage liver disease by analyzing transcriptomic changes and cytokine profiles in muscle and plasma.

This study uses single-cell RNA sequencing to analyze how hypertrophic burn scars respond to carbon dioxide laser therapy, identifying gene expression patterns and cell types associated with good or poor outcomes.

This study finds increased intermuscular adipose tissue in chronic liver disease patients compared to controls, associated with altered muscle gene expression and reduced muscle function.

This study shows that physical activity alters the metabolic profiles of CD4+ and CD8+ T cells in older adults, both at rest and upon activation, potentially improving T cell function.

This paper introduces a framework to build saliva-based DNA methylation biomarkers, demonstrating a new epigenetic clock (InflammAge) that quantifies systemic chronic inflammation and outperforms CRP in several health outcomes.

The paper identifies 995 genes with shared genetic links to age-related diseases using GWAS data and presents them in a web tool for drug target prioritization.

SIMON is an open-source platform that enables biomedical researchers to apply machine learning algorithms to high-dimensional data without requiring advanced programming skills.