Increased utrophin expression in healthy and DMD patient derived myoblasts in response to ERK1/2 and EZH2 inhibitor treatment
Hannah J. Gleneadie, Thomas Francis, Stephanie P L Mo, Aisha Ahmed, Mona Bensalah, Francesco Muntoni A, Stephen D. R. Harridge, Matthias Merkenschlager, Amanda G. Fisher
The paper shows that ERK1/2 and EZH2 inhibitors increase utrophin expression in myoblasts from healthy and DMD patients, with sustained effects in patient-derived cells.
bioRxiv · Apr 15, 2026 · PreprintPharmacology & Toxicology