Amanda G. Fisher

The paper investigates how spatial and transcriptional dynamics at Cd4 and Cd8 loci influence T cell lineage choice in the thymus, revealing locus-specific chromatin environments that drive differentiation.

The paper shows that mouse metaphase chromosomes from different cell types have distinct biomechanical properties, with ESC-derived chromosomes showing conserved force-dependent responses but differing from those of NSCs and preB cells.

The paper shows that ERK1/2 and EZH2 inhibitors increase utrophin expression in myoblasts from healthy and DMD patients, with sustained effects in patient-derived cells.

The paper develops a self-sustained fungal bioluminescence system in animal models to monitor molecular events non-invasively.

The paper uses GAM to study haplotype-specific 3D chromatin structures in mESCs, finding extensive allelic differences in chromatin architecture and gene expression mediated by Polycomb repression.

The paper shows PBK/TOPK phosphorylates Ikaros, Aiolos, and CTCF to displace them from mitotic chromosomes, altering chromatin accessibility at specific zinc finger protein sites.

The paper shows that loss of H3K9 tri-methylation leads to smaller, more compact mitotic chromosomes and altered transcription factor retention.

The paper shows that cohesin's role in neuronal gene expression depends on chromatin loop length, with longer loops requiring cohesin for full gene expression.

The paper shows that maternal high-fat diet induces epigenetic changes in mice that affect two generations, with altered Dlk1 expression and DNA methylation.