Identifying and targeting key driver genes for collagen production within the 11q13/14 breast cancer amplicon
Daniela Araiza‐Olivera, Tatiana Y. Prudnikova, Cristina Uribe‐Alvarez, Kathy Qi Cai, Janusz Franco‐Barraza, Jesús M. Dones, Ronald T. Raines, Jonathan Chernoff
This study identifies P4HA3 and SERPINH1 as key driver genes for collagen production in IntClust-2 breast cancer, showing their role in cell viability, proliferation, and migration, and demonstrates that targeting these genes can reduce tumor growth.
Molecular Cancer Research · Jan 21, 2025Peer-reviewedCancer Biology