Ronald T. Raines

This paper develops a cell-permeable anti-CRISPR protein (6xNLS-Acr) that efficiently inhibits Cas9 activity in human cells, enhancing genome-editing specificity.

This study shows a short peptide can replace an essential enzyme in yeast, demonstrating peptide-based catalysis as a possible precursor to modern protein enzymes.

This study investigates how RNase A and RNase 1 cleave pseudouridine and its derivatives, finding that UpA is cleaved more efficiently than {Psi}pA or m1{Psi}pA.

This paper develops a protein-based delivery system for anti-CRISPR proteins to precisely control Cas9 activity, reducing off-target effects and improving genome editing specificity.

This study identifies P4HA3 and SERPINH1 as key driver genes for collagen production in IntClust-2 breast cancer, showing their role in cell viability, proliferation, and migration, and demonstrates that targeting these genes can reduce tumor growth.

The paper introduces a deep learning model that improves PTM prediction by incorporating known PTM sites into the training process, resulting in better performance than existing models.

The paper demonstrates that endosomolytic peptides L17E and L17ER4 effectively deliver PNAs into human cells, enabling corrective splicing.