Jonathan Chernoff

This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.

This study identifies P4HA3 and SERPINH1 as key driver genes for collagen production in IntClust-2 breast cancer, showing their role in cell viability, proliferation, and migration, and demonstrates that targeting these genes can reduce tumor growth.

This study shows that PAK1 regulates OPC proliferation and repopulation, with mutations affecting oligodendroglial development and myelination.