Resolving Immune Lineage and Cell-State Heterogeneity in Human PBMCs via Mass Spectrometry-Based Single-Cell Proteomics
Samantha A. O’Connor, Romell B. Gletten, Ritin Sharma, Zoe N. Jensen, Brooke Lovell, Krystine Garcia‐Mansfield, Lucy Y. Ghoda, Bin Zhang, David Eugene Frankhouser, Russell C. Rockne, Jeffrey M. Trent, Guido Marcucci, Patrick Pirrotte
The paper develops a pipeline for protein-level cell annotation in human PBMCs using mass spectrometry-based single-cell proteomics and validates it on unsorted samples.
bioRxiv · Jul 30, 2026 · PreprintBioinformatics