Patrick Pirrotte

The paper identifies reduced Golgi enzymes MAN1A1 and MAN1A2 in ALS-associated microglia and astrocytes, linking impaired glycan metabolism to neuroinflammation and disease mechanisms.

The paper uses long-read sequencing to identify novel lncRNAs generated by SF3B1 mutation and shows they produce functional peptides linked to cancer prognosis.

This study uses subcellular spatial proteomics to map protein localization in Capsaspora owczarzaki, a close animal relative, identifying 3,106 high-confidence localizations across 13 compartments.

This study uses subcellular spatial proteomics to map protein localization in Cafeteria roenbergensis, identifying 2,945 proteins across 14 compartments.

This study shows that targeting heparan sulfate proteoglycans in pancreatic cancer with bacterial heparinase III reduces survival signaling and metabolic adaptation, potentially improving therapy efficacy.

This study creates the first global subcellular localization map of Dictyostelium discoideum proteins using subcellular fractionation and mass spectrometry, identifying 3,169 high-confidence localizations across 17 compartments.

This study identifies a tRNA-derived small RNA that reduces cardiac fibrosis and hypertrophy through cell-type-specific mechanisms in mouse and human cardiac cells.

This study uses multi-omic profiling of synaptosomes to identify molecular changes in C9-FTD, revealing disrupted synaptic pathways and localized cryptic transcripts.

This study compares serum metabolomics responses to traditional combined exercise and high-intensity tactical training in young adults, finding similar patterns but greater magnitude changes with traditional exercise.

The paper develops a pipeline for protein-level cell annotation in human PBMCs using mass spectrometry-based single-cell proteomics and validates it on unsorted samples.

This study shows that higher dietary fiber intake improves survival and reduces GVHD in hematopoietic cell transplant patients, with microbiome-mediated effects.

This study identifies immunometabolic factors in CD19 CAR T cells that predict long-term response in B-ALL patients and suggests mTOR inhibition as a strategy to enhance anti-tumor activity.

This paper identifies small nucleolar RNAs (snoRNAs) as potential liquid biomarkers for radiation-induced senescence in glioblastoma by analyzing extracellular vesicle cargo changes.

This study shows STX4 is essential for mitochondrial homeostasis in skeletal muscle by regulating mitochondrial biogenesis and mitophagy.

This study uses human placental organoids to investigate trophoblast subtypes' roles in modulating maternal immune responses and shows 3D culture affects immunomodulation differently than 2D culture.

This study uses engineered 3D hydrogels to generate placental organoids and shows they support trophoblast viability and differentiation comparable to Matrigel.

This study shows that glucose-regulated O-GlcNAcylation of DNMT1 inhibits its methyltransferase activity, leading to epigenome changes and increased DNA damage.

The paper compares transcriptomic responses in skeletal muscle and extracellular vesicles after traditional and high-intensity exercise in young adults, finding more consistent gene responses to traditional exercise and unique microRNA responses to high-intensity training.

This study shows SYNGAP1, an autism risk gene, is expressed in human cortical progenitors and its dysfunction disrupts neurogenesis and cortical lamination.

This study characterizes urine cfDNA fragmentation patterns and shows they reflect sub-nucleosomal organization, with potential for cancer diagnostics.

Bisbee detects differential splicing and identifies splice outliers with improved sensitivity and specificity using proteomics validated methods.