Targeting Non-Catalytic Sites of SRC Sensitizes the Efficacy of SRC Kinase Inhibitors in Solid Tumors
Jinmei Yu, Xusheng Wang, Pengyue Liu, Zhenhe Wang, Jianli Liu, Qianwen Zhang, Zewen Zhang, Tian Gan, Ning Xu, Jichao Zhou, Jiaojiao Yu, Hongyu Yuan, Xinchao Ban, Pingping Li, Xiaowei Zhang, Bing Cui
This study identifies non-catalytic SRC functions as a mechanism of resistance to SRC kinase inhibitors and presents TS1-2 as a peptide that enhances inhibitor efficacy in solid tumors.
bioRxiv · Feb 15, 2025 · PreprintCancer Biology