Ning Xu

Plant LRR-Malectin receptor kinase IGP1 binds cellooligomers via its leucine-rich repeat domain while a conserved cysteine pair in its malectin domain senses hydrogen peroxide to attenuate immune signaling.

This study identifies non-catalytic SRC functions as a mechanism of resistance to SRC kinase inhibitors and presents TS1-2 as a peptide that enhances inhibitor efficacy in solid tumors.