Saxitoxin potentiates Zika virus-induced cell death in human neurons but not in neural progenitors and astrocytes
Letícia R. Q. Souza, Carolina da S. G. Pedrosa, Teresa Puig‐Pijuan…·Marília Zaluar P. Guimarães
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Universidade Federal do Rio de JaneiroORCID 0000-0002-8251-5010Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
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Letícia R. Q. Souza, Carolina da S. G. Pedrosa, Teresa Puig‐Pijuan…·Marília Zaluar P. Guimarães
Teresa Puig‐Pijuan, Letícia R. Q. Souza, Carolina da S. G. Pedrosa…·Stevens Kastrup Rehen
This study shows that ZIKV infection disrupts copper homeostasis in human astrocytes, leading to oxidative stress and cell death, and that copper chelation can reduce oxidative stress and improve cell viability.
Carolina da S. G. Pedrosa, Livia Goto‐Silva, Jairo Ramos Temerozo…·Marília Zaluar P. Guimarães
This study shows SARS-CoV-2 infection of human neural cells is non-permissive but causes inflammation and cell damage, suggesting neural damage in COVID-19 is due to systemic inflammation rather than direct viral replication.