Livia Goto‐Silva

The paper compares proteomic profiles of hiPSC-derived neural stem cells in 2D monolayers and 3D neurospheres, finding neurospheres show neural pathway enrichment and increased neuronal identity.

The paper compares proteomic complexity across human neural models, finding increased molecular complexity in tissue-like models that better reflect in vivo brain biology.

This study shows that Oropouche virus strains cause microcephaly-like effects in brain organoids by disrupting neural development and inducing cell death and apoptosis.

This study uses proteomics to show LSD alters proteins involved in proteostasis, energy metabolism, and neuroplasticity in human brain organoids.

This study investigates how DYRK1A affects APP vesicle transport in human neurons, finding that its inhibition reduces retrograde transport while overexpression increases it.

This study shows SARS-CoV-2 infection of human neural cells is non-permissive but causes inflammation and cell damage, suggesting neural damage in COVID-19 is due to systemic inflammation rather than direct viral replication.

This study quantifies proteomic changes during human neurosphere differentiation, identifying upregulated axon guidance pathways and a functional assay for neurite outgrowth.

This study shows that d-LSD enhances novel object preference in young and adult rats and can rescue this effect in old rats when combined with enriched environment exposure.