Stevens Kastrup Rehen

The paper identifies ZNF560 as an epigenetic marker in schizophrenia iPSCs, showing impaired repression and altered gene regulation during reprogramming.

This study shows CDK4/6 inhibitors synergize with oxaliplatin in colorectal cancer, with RB-dependent tumor-selective activity and preserved efficacy at low inhibitor doses.

The paper compares proteomic profiles of hiPSC-derived neural stem cells in 2D monolayers and 3D neurospheres, finding neurospheres show neural pathway enrichment and increased neuronal identity.

The paper compares proteomic complexity across human neural models, finding increased molecular complexity in tissue-like models that better reflect in vivo brain biology.

The paper shows that SCZ astrocytes, when stimulated, induce a dystrophic phenotype in microglial-like cells through altered cytokine profiles and impaired phagocytosis.

This study shows that Oropouche virus strains cause microcephaly-like effects in brain organoids by disrupting neural development and inducing cell death and apoptosis.

This study shows that LSD extends lifespan and reduces age-related decline in C. elegans, suggesting it modulates conserved nutrient-sensing pathways linked to longevity.

This study uses proteomics to show LSD alters proteins involved in proteostasis, energy metabolism, and neuroplasticity in human brain organoids.

This study shows that hiPSC-derived astrocytes from schizophrenia patients have an inflammatory phenotype that reduces vascularization through secreted factors like IL-8.

This study investigates how DYRK1A affects APP vesicle transport in human neurons, finding that its inhibition reduces retrograde transport while overexpression increases it.

This study shows that ZIKV infection disrupts copper homeostasis in human astrocytes, leading to oxidative stress and cell death, and that copper chelation can reduce oxidative stress and improve cell viability.

This study shows that reduced lipoxin A4 levels in aging brains contribute to cognitive deficits in mice and humans, suggesting LXA4 as a potential therapeutic target for age-related dementia.

This study shows SARS-CoV-2 infection of human neural cells is non-permissive but causes inflammation and cell damage, suggesting neural damage in COVID-19 is due to systemic inflammation rather than direct viral replication.

This study shows that oligomeric α-synuclein reduces keratinocyte proliferation and induces inflammation in a reconstructed human epidermis model.

This study quantifies proteomic changes during human neurosphere differentiation, identifying upregulated axon guidance pathways and a functional assay for neurite outgrowth.

This paper investigates whether saxitoxin from cyanobacteria worsens neural damage caused by Zika virus in Brazil, finding increased cell death and brain abnormalities in experimental models.

This study shows that human iPSC-derived astrocytes exposed to TNF-alpha recapitulate key astrogliosis features over time, including cytokine secretion, morphological changes, and reduced aspartate uptake.

This study shows that d-LSD enhances novel object preference in young and adult rats and can rescue this effect in old rats when combined with enriched environment exposure.

This study describes a method to generate functional human peripheral sensory neurons from hiPSCs that release substance P in response to TRPV1 agonists.

This study investigates proteomic changes in human cerebral organoids treated with 5-MeO-DMT, identifying 934 differentially expressed proteins and suggesting anti-inflammatory and synaptic modulation effects.