Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to Aspergillus fumigatus in cystic fibrosis
Amelia Bercusson, Thomas J Williams, Nicholas J. Simmonds, Eric W.F.W. Alton, Uta Griesenbach D, Anand Shah, Adilia Warris, Darius P. H. Armstrong-James
This study shows that CFTR deficiency increases NFAT and NFκB signaling in response to Aspergillus fumigatus, leading to hyperinflammation and reduced fungal control in cystic fibrosis.
PLoS Pathogens · Feb 4, 2025Peer-reviewedImmunology