Thomas J Williams

Mycobacterial lipoarabinomannan negatively interferes with macrophage responses to Aspergillus fumigatus in-vitro

This study shows that mycobacterial lipoarabinomannan impairs macrophage ability to kill Aspergillus fumigatus conidia and increases inflammatory cytokine release in vitro.

Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease

This study identifies IL-1RAP as a target for reducing eosinophilia in allergic fungal airway disease using a mouse model of chronic A. fumigatus exposure.

Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to Aspergillus fumigatus in cystic fibrosis

This study shows that CFTR deficiency increases NFAT and NFκB signaling in response to Aspergillus fumigatus, leading to hyperinflammation and reduced fungal control in cystic fibrosis.

Precision-cut lung slices in air-liquid interface (PCLS-ALI): A novel ex-vivo model for the study of Pulmonary Aspergillosis

The paper introduces a novel ex-vivo model using precision-cut lung slices in air-liquid interface to study Pulmonary Aspergillosis and assess antifungal treatments.