Daniele Vigolo

Symmetry-breaking flow transition as an under-recognized hemodynamic factor in valve-associated thrombosis

This study identifies symmetry-breaking flow transitions in venous valves as a key factor in creating transport heterogeneity linked to thrombosis.

Elevated hydrostatic pressure modulates endothelial junctional mechanotransduction through VE-cadherin remodelling and altered association with YAP1, EPS8: an endothelium-on-chip study

This study investigates how elevated hydrostatic pressure affects endothelial junctions using an endothelium-on-chip model, revealing changes in VE-cadherin structure, YAP1 localization, and EPS8 interactions.

A Reduced Mechanobiological Framework for Platelet Priming: From Hemodynamic Shear to Mechanosensitive Calcium Entry

The paper develops a reduced mechanobiological framework linking hemodynamic shear to mechanosensitive calcium entry in platelets, identifying a conditioning-test protocol to distinguish memory effects from other priming mechanisms.

Force-Gated Thrombosis (FGT): A Non-Equilibrium Mechanical Theory of Shear-Induced Blood Clot Initiation

This paper introduces a non-equilibrium mechanical theory, Force-Gated Thrombosis (FGT), to predict shear-induced blood clot formation across vascular geometries using experimental and computational datasets.

Fluorescently Labeled Gradient Hydrogels Reveal Matrix-Dependent Cell Responses to Substrate Stiffness

This paper introduces a thermophoresis-based method to create stiffness gradient hydrogels and demonstrates their impact on cell morphology and migration.

A Modular Microfluidic System to Generate Gradient Hydrogels with Simple-to-Complex Stiffness Profiles for Mechanobiology

This paper introduces a modular microfluidic system to create stiffness gradient hydrogels with complex profiles, showing their effectiveness in modulating cell behavior.

DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates

This study investigates how DNA partitioning affects the phase behavior and dynamics of FUS condensates, revealing its role in modulating liquid-to-solid transitions and microstructure over time.

Neuromorphic Imaging Cytometry on Human Blood Cells

This paper introduces a neuromorphic imaging cytometry system for human blood cells, achieving high accuracy with reduced resource usage.

Elevated hydrostatic pressure acts via piezo-1 to destabilise VE-cadherin junctions: an endothelium-on-chip study

This study shows elevated hydrostatic pressure affects VE-cadherin junctions via piezo-1, with effects dependent on shear stress duration and intensity.