Yi Shen

This study shows that the conformational state of RIPK3 RHIM domain determines whether it forms reversible condensates or amyloid fibrils, revealing a dual role for phase separation in amyloid formation.

This paper demonstrates that coacervate droplets can reverse solid RNA-peptide aggregates into functional liquid droplets, offering a method to manage pathological aggregation.

This paper introduces a modular microfluidic system to create stiffness gradient hydrogels with complex profiles, showing their effectiveness in modulating cell behavior.

This study shows thermal cycling can delay irreversible fiber formation in aged biomolecular condensates and preserve their stability.

This study investigates how DNA partitioning affects the phase behavior and dynamics of FUS condensates, revealing its role in modulating liquid-to-solid transitions and microstructure over time.