Cancer BiologybioRxivPreprint
A trimeric USP11/USP7/TCEAL1 complex stabilizes RNAPII during early transcription to sustain oncogenic gene expression
Markus Dehmer, Peter Gallant, Steffi Herold…·Gabriele Büchel
1 citation
Author
Peter Gallant
University of WürzburgORCID 0000-0002-8270-5738Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2024 · peak 4/yrCo-Author Collaboration Network
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Carsten Patrick AdeORCID
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4 papers
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- Molecular BiologyeLifePeer-reviewed
Association with TFIIIC limits MYCN localization in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA Polymerase II
Raphael Silveira Vidal, Eoin N. Leen, Steffi Herold…·Gabriele Büchel
The paper shows that TFIIIC binds MYCN and limits non-phosphorylated RNA Polymerase II accumulation at promoters, but does not affect MYCN-dependent gene expression or transcription elongation.
- Molecular BiologybioRxiv
NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4
Victoria Mamontova, Barbara Trifault, Anne-Sophie Gribling-Burrer…·Kaspar Burger
This study identifies NEAT1 as a regulator of genome stability through m6A methylation-dependent control of CHD4 in response to DNA damage.
16 citations - Molecular BiologyNucleic Acids ResearchPeer-reviewed
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts
Barbara Trifault, Victoria Mamontova, Giacomo Cossa…·Kaspar Burger
The paper shows that NONO relocalizes to the nucleolus via diNARs to shield DNA breaks from aberrant transcripts, promoting repair.
24 citations