Targeted Irradiation and STAT3 Inhibition Reprogram the AML Microenvironment and Extend Survival: Toward Translational Immunoradiotherapy
Srideshikan Sargur Madabushi, Jamison Brooks, Darren M. Zuro, Yu‐Lin Su, Damian Kaniowski, Hemendra Ghimire, Ji Eun Lim, Amr M H Abdelhamid, Ya‐Huei Kuo, Guido Marcucci, Jeffrey Y.C. Wong, Monzr M. Al Malki, Anthony Selwyn Stein, Marcin Kortylewski, Susanta Kumar Hui
This study combines targeted marrow irradiation with a STAT3 inhibitor to improve leukemia clearance and immune memory in AML models.
bioRxiv · May 14, 2025 · PreprintImmunology