This study uses MRI and micro-CT to show that marrow irradiation and transplantation in a sickle cell disease model partially restores bone marrow structure and function.

bioRxiv · Dec 11, 2025 · PreprintBioengineering

Targeted Irradiation and STAT3 Inhibition Reprogram the AML Microenvironment and Extend Survival: Toward Translational Immunoradiotherapy

Srideshikan Sargur Madabushi, Jamison Brooks, Darren M. Zuro, Yu‐Lin Su, Damian Kaniowski, Hemendra Ghimire, Ji Eun Lim, Amr M H Abdelhamid, Ya‐Huei Kuo, Guido Marcucci, Jeffrey Y.C. Wong, Monzr M. Al Malki, Anthony Selwyn Stein, Marcin Kortylewski, Susanta Kumar Hui

This study combines targeted marrow irradiation with a STAT3 inhibitor to improve leukemia clearance and immune memory in AML models.

bioRxiv · May 14, 2025 · PreprintImmunology

Development of Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantitative Assessment of Bone Marrow Changes with Age and Radiation in Mouse Models

Hemendra Ghimire, Malakeh Malekzadeh, Ji Eun Lim, Srideshikan Sargur Madabushi, Marco Andrea Zampini, Angela Camacho, Weidong Hu, Natalia Baran, Guy A Storme, Monzr M. Al Malki, Susanta Kumar Hui

This paper develops a PDFF MRI technique to quantify bone marrow fat fraction in mice, showing significant differences with age and radiation, validated by histology.

Bioengineering · Mar 28, 2025Peer-reviewedBiophysics