Damian C. Ekiert

Live-cell imaging and ultrastructure expansion microscopy reveal the dynamic intracellular life cycle of the microsporidian parasite Encephalitozoon intestinalis

Single-cell transcriptomics of Encephalitozoon intestinalis infection in Caco-2 and Vero cells

The paper uses scRNA-seq to study host and parasite transcriptional responses to Encephalitozoon intestinalis infection in Caco-2 and Vero cells, finding limited host response and a parasite developmental program.

Interactions of outer membrane lipoproteins P. aeruginosa PA3214 and E. coli PqiC with their MCE protein binding partners, PA3213 and PqiB

The paper reports cryo-EM structures of P. aeruginosa PA3214 and E. coli PqiC lipoproteins interacting with their MCE protein partners, revealing their assembly and functional interactions.

Polar tube firing dynamics and ultrastructure from the shrimp microsporidian Ecytonucleospora hepatopenaei (EHP)

This study investigates the polar tube firing dynamics and ultrastructure of EHP, identifying optimal activation conditions and revealing structural features important for infection.

Bond-centric modular design of protein assemblies

The paper introduces a modular bond-centric design approach for protein assemblies, demonstrating the successful creation of multiple polyhedral cages, 2D arrays, and 3D lattices with high success rates.

scRNA-seq reveals transcriptional dynamics of Encephalitozoon intestinalis parasites in human macrophages

This study uses scRNA-seq to analyze transcriptional changes in human macrophages and Encephalitozoon intestinalis parasites during infection, revealing parasite developmental dynamics and host response.

LetA defines a structurally distinct transporter family involved in lipid trafficking

The paper determines the structure of E. coli LetAB, identifies LetA as a novel transporter family, and proposes a mechanism for lipid transport using proton-motive force.

Cryo-ET reveals the in situ architecture of the polar tube invasion apparatus from microsporidian parasites

The paper uses cryo-electron tomography to reveal the in situ architecture of the polar tube invasion apparatus in microsporidian parasites.

Characterization of a cytokinin-binding protein locus in Mycobacterium tuberculosis

The paper identifies a cytokinin-binding protein in M. tuberculosis and shows it binds cytokinins with high specificity, suggesting cytokinins may have roles in mycobacterial physiology.

Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis

The paper identifies CoaX, a pseudokinase, and pantothenate as regulators of proteasomal degradation of the pantothenate synthesis enzyme PanB in M. tuberculosis.