ImmunologybioRxivPreprint
A multivalent mRNA-LNP therapeutic vaccine with broad cross-genotype immunogenicity elicits clearance of HBV infected hepatocytes
Daniel L. Makrinos, Yanbo Sun, Heather L. Davis…·Simone Pecetta
This paper develops an mRNA-LNP vaccine, mRNA-1965, that clears HBV-infected hepatocytes in mice by inducing broad immune responses across HBV genotypes.
DOI 10.64898/2025.12.03.692117