Andrea Carfı́

The paper develops a risk calculator to predict immune escape of SARS-CoV-2 variants and group antigenically related variants to guide vaccine strain selection.

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

This paper demonstrates the feasibility of expressing monoclonal IgG and IgA antibodies in non-human primates using mRNA-LNPs, showing both isotypes retain HIV-neutralizing function and native-like glycosylation.

This paper develops an mRNA-LNP vaccine, mRNA-1965, that clears HBV-infected hepatocytes in mice by inducing broad immune responses across HBV genotypes.

This study develops and evaluates two mRNA vaccines targeting the LP.8.1 variant of SARS-CoV-2, showing broad neutralization against JN.1-lineage subvariants.

This study demonstrates that mRNA-LNPs can deliver pathogen-specific monoclonal IgG into breast milk, enabling transfer of functional antibodies to suckling mice.

This study evaluates JN.1 and KP.2 mRNA vaccines in mice, showing they elicit strong neutralizing antibodies against JN.1 subvariants and cross-neutralize KP.3, LA.2, and XEC.

The paper shows that an mRNA vaccine against mpox reduces virus replication at multiple inoculation sites and provides protection with a single dose, supported by antibody-mediated immunity.