Author

Alec W. Freyn

Moderna Therapeutics (United States)ORCID 0000-0002-5963-8995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:multiome· 1 Organism:non-human primate· 1

Frequent Co-Authors

Andrea Carfı́iD· 3 shared Cathal HarmoniD· 2 shared Daniel L. MakrinosiD· 2 shared Kath Hardcastle· 2 shared Ziqiu WangiD· 2 shared Adrian R. LaciakiD· 1 shared Amy Gorrie· 1 shared Anthony T. DiPiazzaiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

Andrea Carfı́ORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 5, 2025

A multivalent mRNA-LNP therapeutic vaccine with broad cross-genotype immunogenicity elicits clearance of HBV infected hepatocytes

Daniel L. Makrinos, Yanbo Sun, Heather L. Davis…·Simone Pecetta

This paper develops an mRNA-LNP vaccine, mRNA-1965, that clears HBV-infected hepatocytes in mice by inducing broad immune responses across HBV genotypes.

DOI 10.64898/2025.12.03.692117

mousenon-human primate

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ImmunologybioRxivPreprintSep 16, 2025

mRNA-1273.251 and mRNA-1283.251 vaccines expressing SARS-CoV-2 variant LP.8.1 antigens broadly neutralize contemporary JN.1-lineage viruses

Arshan Nasir, Diana Wing Lee, Ziqiu Wang…·Alec W. Freyn

This study develops and evaluates two mRNA vaccines targeting the LP.8.1 variant of SARS-CoV-2, showing broad neutralization against JN.1-lineage subvariants.

1 citation

mouseexperimental assay

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Microbiologynpj VaccinesPeer-reviewedDec 24, 2024

Mpox mRNA-1769 Vaccine Inhibits Orthopoxvirus Replication at Intranasal, Intrarectal, and Cutaneous Sites of Inoculation

Catherine A. Cotter, Maxinne A. Ignacio, Jeffrey L. Americo…·Bernard Moss

The paper shows that an mRNA vaccine against mpox reduces virus replication at multiple inoculation sites and provides protection with a single dose, supported by antibody-mediated immunity.

17 citations

mouseexperimental assay

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