ImmunologybioRxivPreprint
Tumor cell-intrinsic mtDNA instability drives cGAS-dependent temporal remodeling of the melanoma immune microenvironment
Abate Assefa Bashaw, Ashley D. Winters, Yuanjiu Lei…·Andrew Phillip West
This study shows that tumor cell-intrinsic mtDNA instability drives temporal changes in the melanoma immune microenvironment through cGAS, affecting immune cell states and therapeutic response.
DOI 10.64898/2026.09.28.755003