Ashok Kumar Shetty

This study shows that extracellular vesicles from hiPSC-derived neural stem cells protect human neurons from Aβ-42 oligomer-induced neurodegeneration, mitochondrial dysfunction, and tau phosphorylation.

This study shows that intranasal hiPSC-NSC-EVs reduce neuroinflammaging in aged mice by modulating microglial transcriptome and signaling pathways.

This study examines the effects of short-term CSF1R inhibition in 5xFAD mice, showing reduced microglia, noninflammatory phenotype, and altered signaling pathways without affecting Aβ plaques.

This study shows that intranasally administered EVs from hiPSC-derived NSCs reduce microglial activation and improve brain function in an Alzheimer's model.

This study shows that GWIC exposure affects mitochondrial function and innate immune signaling in mice, leading to neurocognitive impairments and sex-specific differences.