Gerald S. Shadel

This study shows that tumor cell-intrinsic mtDNA instability drives temporal changes in the melanoma immune microenvironment through cGAS, affecting immune cell states and therapeutic response.

This study identifies an IL-10/ACOD1 axis that reprograms lipid metabolism in trained macrophages to promote resolution of inflammation.

The paper shows that cGAS hyperactivates in response to unpaired DNA (Bu-DNA) by bending it into a V-shape, revealing a new activation mechanism.

This study identifies phosphorylation sites in BCL2L13 regulated by AMPK and TBK1, revealing a novel mechanism for mitophagy regulation.

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.

This study shows INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement through high-resolution imaging and genetic manipulation.