Yuanjiu Lei

Tumor cell-intrinsic mtDNA instability drives cGAS-dependent temporal remodeling of the melanoma immune microenvironment

This study shows that tumor cell-intrinsic mtDNA instability drives temporal changes in the melanoma immune microenvironment through cGAS, affecting immune cell states and therapeutic response.

Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging

This study shows that reducing cysteine, not methionine, improves immunometabolic fitness and extends healthy lifespan in aging organisms.

Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

This study identifies caspase-11 as a driver of macrophage hyperinflammation in Polg-related mitochondrial disease models, linking IFN-I signaling to exacerbated infection outcomes.

The Age-Dependent Decline in Neuron Growth Potential in the CNS is Associated with an Age-Related Dysfunction of Neuronal Mitochondria

This study shows that aging reduces neuron growth potential in the CNS by impairing mitochondrial function in mice.