Author

José A. Brito

Instituto de Tecnologia Química e Biológica António XavierORCID 0000-0002-8307-2282Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ana C. C. BarbosaiD· 1 shared Andreia I. PimentaiD· 1 shared Andrew T. PooreiD· 1 shared Arpita GoswamiiD· 1 shared Bonnie J. MurphyiD· 1 shared Brenna J. C. WalshiD· 1 shared Casey Van StappeniD· 1 shared David P. GiedrociD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperMicrobiology

Ana C. C. BarbosaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Self-S-sulfonation in a bacterial persulfide dioxygenase mediates thiol persulfide detoxification

Julius O. Campeciño, Sofia Soares Costa, Inês D. S. Pires, Brenna J. C. Walsh, Jonathan C. Trinidad, Jyoti Kannoujia, Andrew T. Poore, Casey Van Stappen, Giovanni González-Gutiérrez, Margarida Archer, Miguel Machuqueiro, José A. Brito, David P. Giedroc

This paper identifies a self-S-sulfonation mechanism in bacterial persulfide dioxygenase CstB that converts thiol persulfides to thiosulfate without sulfite release.

Communications Chemistry · Sep 22, 2026Peer-reviewedBiochemistry

Structural basis of sulfide production in dissimilatory sulfur metabolism

Dongsheng M. Yin, Raquel M. Bernardino, Ana C. C. Barbosa, José A. Brito, Andreia I. Pimenta, Sonja Welsch, Filipa L. Sousa, Inês A. C. Pereira, Bonnie J. Murphy

This study reveals the structural basis of sulfide production in dissimilatory sulfur metabolism through cryo-EM structures of the DsrMKJOP complex from Archaeoglobus fulgidus.

bioRxiv · Aug 25, 2026 · PreprintMicrobiology

Horizontally acquired HosA transcription factor bound with 4-hydroxy-benzoic acid exhibits unique tug-of-water dynamics

Arpita Goswami, Samee Ullah, José A. Brito

This study elucidates the crystal structure of HosA from pathogenic E. coli and reveals unique water molecule dynamics in its PHB-bound form, along with its horizontal gene transfer origin from Shigella.

bioRxiv · Apr 24, 2024 · PreprintBiochemistry