Sonja Welsch

The paper elucidates the structural mechanism of nuclear membrane sealing by LEM2-ESCRT-III through a combination of biochemical and structural methods.

This study reveals the structural basis of sulfide production in dissimilatory sulfur metabolism through cryo-EM structures of the DsrMKJOP complex from Archaeoglobus fulgidus.

This paper introduces ValidaTe, a framework to predict and mitigate off-target liabilities in TCR-mimic antibodies, demonstrating its effectiveness with CTA MAGE-A4 targets.

This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

This paper introduces a combined MSI and cryo-ET pipeline for reliable single-cell classification in cryo-ET samples, enabling post-acquisition cell identification and classification.

This study investigates how HIV-1 capsids pass through nuclear pores, finding that capsids retain their structure and cause NPC scaffold rings to crack.

The paper identifies the palisade layer of the vaccinia virus core as composed of flexible A10 trimers using cryoET, STA, and AlphaFold2.

This study uses cryo electron tomography and simulations to analyze the structure of SARS-CoV-2 spike protein in situ, revealing three hinges in the stalk domain that enable orientational flexibility.