The paper shows that genetic inactivation of the beta1 adrenergic receptor reduces cerebral cavernous malformations in zebrafish, supporting propranolol's therapeutic effect through beta1 receptor antagonism.

eLife · Feb 14, 2025Peer-reviewedDevelopmental Biology

Blood-based Genomic and Cellular Determinants of Response to Neoadjuvant PD-1 Blockade in Patients with Non-Small-Cell Lung Cancer

Xi Zhang, Rui Chen, Wenqing Li, Shengchao Zhang, Mengju Jiang, Guodong Su, Yuru Liu, Yu Cai, Wuhao Huang, Yuyan Xiong, Shengguang Wang

The paper identifies blood-based genomic and cellular biomarkers predictive of response to neoadjuvant PD-1 blockade in NSCLC patients using transcriptomic and mutation analysis.

medRxiv · Dec 7, 2021 · PreprintGenetic & Genomic Medicine

Abortive Intussusceptive Angiogenesis Causes Multi-Cavernous Vascular Malformations

Wenqing Li, Virginia Tran, Iftach Shaked, Belinda Xue, Thomas Moore, Rhonda Lightle, David Kleinfeld, Issam A. Awad, Mark H. Ginsberg

This study shows that mosaic inactivation of ccm2 in zebrafish leads to abortive intussusceptive angiogenesis, causing multi-cavernous vascular malformations similar to human cerebral cavernous malformations.

eLife · May 20, 2021Peer-reviewedDevelopmental Biology