Author
University of ChicagoORCID 0000-0002-9540-2971Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Wenqing Li, Virginia Tran, Iftach Shaked, Belinda Xue, Thomas Moore, Rhonda Lightle, David Kleinfeld, Issam A. Awad, Mark H. Ginsberg
This study shows that mosaic inactivation of ccm2 in zebrafish leads to abortive intussusceptive angiogenesis, causing multi-cavernous vascular malformations similar to human cerebral cavernous malformations.
eLife · May 20, 2021Peer-reviewedDevelopmental Biology
Miguel Alejandro Lopez‐Ramirez, Shady Ibrahim Soliman, Preston Hale, Catherine Chinhchu Lai, Angela Pham, Esau J. Estrada, Sara McCurdy, Romuald Girard, Riya Verma, Thomas Moore, Rhonda Lightle, Nicholas Hobson, Robert Shenkar, Orit Poulsen, Gabriel George Haddad, , Mark H. Ginsberg
The paper shows that astrocytes contribute to cerebral cavernous malformations (CCMs) through VEGF production driven by endothelial NO, highlighting non-cell-autonomous mechanisms.
bioRxiv · Jan 29, 2021 · PreprintNeuroscience
Matthew R. Detter, Robert Shenkar, Christian R. Benavides, Catherine A. Neilson, Thomas Moore, Rhonda Lightle, Nicholas Hobson, Le Shen, Ying Jun Cao, Romuald Girard, Dongdong Zhang, Erin Griffin, Carol J. Gallione, Issam A. Awad, Douglas A. Marchuk
This paper develops new mouse models of cerebral cavernous malformations (CCMs) to better study drug therapies for CCM formation and hemorrhage.
bioRxiv · Feb 12, 2020 · PreprintGenetics