Author
University of ChicagoORCID 0000-0003-1510-602XUnclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Eduardo Frías-Anaya, Helios Gallego-Gutiérrez, Cassandra Bui…·Miguel Alejandro Lopez‐Ramirez
This paper identifies metformin as a potential drug for long-term treatment of cerebral cavernous malformations using AI, high-throughput screening, and animal models.
Daniel A. Snellings, Romuald Girard, Rhonda Lightle…·Douglas A. Marchuk
The paper identifies PIK3CA mutations in developmental venous anomalies (DVA) and CCM, showing DVA act as a genetic primer for CCM through shared mutations.
Wenqing Li, Virginia Tran, Iftach Shaked…·Mark H. Ginsberg
This study shows that mosaic inactivation of ccm2 in zebrafish leads to abortive intussusceptive angiogenesis, causing multi-cavernous vascular malformations similar to human cerebral cavernous malformations.
Miguel Alejandro Lopez‐Ramirez, Shady Ibrahim Soliman, Preston Hale…·Mark H. Ginsberg
The paper shows that astrocytes contribute to cerebral cavernous malformations (CCMs) through VEGF production driven by endothelial NO, highlighting non-cell-autonomous mechanisms.
Matthew R. Detter, Robert Shenkar, Christian R. Benavides…·Douglas A. Marchuk
This paper develops new mouse models of cerebral cavernous malformations (CCMs) to better study drug therapies for CCM formation and hemorrhage.