TYLER D. HETHER

Tracing colorectal malignancy transformation from cell to tissue scale

This paper traces colorectal cancer progression by integrating spatial transcriptomics, single-nucleus RNA-sequencing, and histopathology to map cellular and molecular changes across tumor stages.

The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs

SAHA creates a multimodal, subcellular-resolution reference atlas of healthy human tissues, revealing spatial organization and disease-associated disruptions across multiple organ systems.

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

Sub-cellular Imaging of the Entire Protein-Coding Human Transcriptome (18933-plex) on FFPE Tissue Using Spatial Molecular Imaging

This paper introduces a high-plex spatial molecular imaging technique capable of sub-cellular transcriptome analysis of FFPE tissues, achieving whole transcriptome coverage with high resolution and minimal dissociation bias.

Background modeling, Quality Control and Normalization for GeoMx RNA data with GeoDiff

The paper introduces a statistical model-based workflow for quality control and normalization of GeoMx RNA data, outperforming conventional methods in reducing background noise and technical variability.

Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and Drug Interactions

This study uses rapid diagnostics and metatranscriptomics to analyze SARS-CoV-2 infection, revealing viral evolution, host responses, and drug interactions in NYC samples.

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

Uplift and erosion of genomic islands with standing genetic variation

This study investigates how divergent selection on standing genetic variation can create genomic islands of divergence, finding two pathways and the role of recombination in their formation.