Author

Cláudia M. Deus

Centro de Inovação em Biomedicina e BiotecnologiaORCID 0000-0002-8344-9182Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. Raquel EstevesiD· 1 shared Carla LopesiD· 1 shared Christine KleiniD· 1 shared Fernanda BorgesiD· 1 shared Fernando CagideiD· 1 shared H TavaresiD· 1 shared Ira MiloševićiD· 1 shared Margarida BeatriziD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

A. Raquel EstevesORCID

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1 paper

Recent·Most cited

Micronuclear collapse under oxidative stress drives amphisome-mediated export of DNA in Parkinson disease

H Tavares, O Gonçalves, Rita Gaspar, Margarida Beatriz, Cláudia M. Deus, Sofia Benfeito, Fernando Cagide, Fernanda Borges, Philip Seibler, Christine Klein, A. Raquel Esteves, Sandra M. Cardoso, Nuno Raimundo, Ira Milošević, Paulo S. Pinheiro, , Carla Lopes

The paper shows that oxidative stress causes micronuclear collapse in Parkinson's fibroblasts, leading to DNA export via amphisomes and pro-inflammatory EVs, which can be mitigated by a mitochondria-targeted antioxidant.

bioRxiv · Dec 2, 2025 · PreprintNeuroscience