Paulo S. Pinheiro

This study identifies hnRNP H2's role in neuronal development and shows how disease variants disrupt its function, leading to neurodevelopmental defects.

This study identifies ARHGAP8 as a novel synaptic protein involved in excitatory synapse morphology and function, with implications for neurodevelopmental and psychiatric disorders.

The paper shows that oxidative stress causes micronuclear collapse in Parkinson's fibroblasts, leading to DNA export via amphisomes and pro-inflammatory EVs, which can be mitigated by a mitochondria-targeted antioxidant.

The paper shows that extracellular vesicles from healthy cells can reverse GABAergic synaptic deficits in Huntington's disease neurons by modulating miRNA content.

This study investigates the roles of synaptotagmin-1 and synaptotagmin-7 in Ca2+-dependent vesicle priming and exocytosis in mouse chromaffin cells, showing their synergistic effects.

This study shows endophilin-A1 and A2 regulate exocytosis of neurosecretory vesicles by controlling recruitment, priming, and fusion, independent of their endocytic roles.