Margarida Beatriz

Micronuclear collapse under oxidative stress drives amphisome-mediated export of DNA in Parkinson disease

The paper shows that oxidative stress causes micronuclear collapse in Parkinson's fibroblasts, leading to DNA export via amphisomes and pro-inflammatory EVs, which can be mitigated by a mitochondria-targeted antioxidant.

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

The paper shows that extracellular vesicles from healthy cells can reverse GABAergic synaptic deficits in Huntington's disease neurons by modulating miRNA content.

Mitochondrial and redox modifications in early stages of Huntington disease

This study investigates mitochondrial dysfunction and redox changes in early Huntington disease stages using human and mouse models, showing increased mitochondrial activity and altered morphology.

Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington's Disease

This study shows that Huntington's Disease leads to increased release of mitochondrial components via extracellular vesicles due to mitochondrial and lysosomal dysfunction.