Direct pathway bias and altered striatal neurogenesis in human iPSC models of 16p11.2 CNVs: Evidence from single-cell and functional analyses
Marija Fjodorova, Parinda Prapaiwongs, Olena Petter, Ilaria Morella, Zongze Li, Jessica H. Hall, Ngoc‐Nga Vinh, Sara Davies, Jonathan Green, Jérémy Hall, Marianne B. M. van den Bree, Riccardo Brambilla, Meng Li
The paper uses human iPSC-derived medium spiny neurons to show that 16p11.2 CNVs alter striatal neurogenesis and bias toward direct pathway neurons, linking these changes to neurodevelopmental disorders.
bioRxiv · Feb 26, 2025 · PreprintNeuroscience