Zongze Li

Autism-associated oxysterol regulates GABAergic neurogenesis and subtype fates

The paper shows that 24S,25-epoxysterol, an oxysterol linked to neurodevelopmental disorders, promotes neurogenesis and disrupts GABAergic neuronal subtype composition through the liver X receptor pathway.

Direct pathway bias and altered striatal neurogenesis in human iPSC models of 16p11.2 CNVs: Evidence from single-cell and functional analyses

The paper uses human iPSC-derived medium spiny neurons to show that 16p11.2 CNVs alter striatal neurogenesis and bias toward direct pathway neurons, linking these changes to neurodevelopmental disorders.

Transcriptomic disruption and functional hypoactivity in DYT-SGCE MGE-patterned inhibitory neurons

This study investigates SGCE mutations' impact on MGE-derived inhibitory neurons, finding transcriptomic dysregulation and functional hypoactivity, contrasting with hyperexcitability in glutamatergic neurons.

Changes in neural progenitor lineage constituent during astrocytic differentiation of human iPSCs

This study shows that astrocytes derived from LMX1A+ progenitors lose lineage composition during differentiation unless progenitors are purified, using deep single-cell RNA sequencing.